ABSTRACT
The present study enlightens to enhance the dissolution rate, absorption efficiency and bioavailability of Nimesulide, a poorly soluble-highly permeable drug by preparing liquisolid compacts. Nimesulide liquisolid tablets were prepared by using polyethylene glycol-400 as a non-volatile liquid vehicle, microcrystalline cellulose, hydroxypropyl methylcellulose-E15, starch were used as carrier materials and silica gel as coating material in different ratios. They were characterized for different physical parameters to comply with pharmacopoeial limits. In vitro dissolution profiles of the liquisolid formulations were studied and compared with conventional formulation in pH 7.4 phosphate buffer and it was found that liquisolid tablets formulated with microcrystalline cellulose showed significant higher drug release rates than conventional tablets due to increase in wetting properties. DSC study showed that there is no interaction between the drug and excipients. In conclusion, development of nimesulide liquisolid tablets is a good approach to enhance the dissolution rate.